Cardenolide Glycosides from Pergularia tomentosa and Their Proapoptotic Activity in Kaposi's Sarcoma Cells
Journal of Natural Products2006Vol. 69(9), pp. 1319–1322
Citations Over TimeTop 13% of 2006 papers
Arafa I. Hamed, Alberto Plaza, Maria Luisa Balestrieri, Usama A. Mahalel, Irina Springuel, Wiesław Oleszek, Cosimo Pìzza, Sonia Piacente
Abstract
Continuing our investigations on plants belonging to the Asclepiadaceae family, three new cardenolide glycosides, 3'-O-beta-D-glucopyranosylcalactin (1), 12-dehydroxyghalakinoside (2), and 6'-dehydroxyghalakinoside (3), along with the known ghalakinoside (4) and calactin (5), were isolated from the roots of Pergularia tomentosa. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments as well as ESIMS analysis. The isolated cardenolides caused apoptotic cell death of Kaposi's sarcoma cells.
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