A Dimeric Lactone from Ardisia japonica with Inhibitory Activity for HIV-1 and HIV-2 Ribonuclease H
Journal of Natural Products2007Vol. 70(5), pp. 839–841
Citations Over TimeTop 10% of 2007 papers
Nguyễn Tiến Đạt, KiHwan Bae, Antony Wamiru, James B. McMahon, Stuart F.J. Le Grice, Marion Bona, John A. Beutler, Young Ho Kim
Abstract
A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.
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