Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest,1
Journal of Natural Products2007Vol. 70(3), pp. 342–346
Citations Over TimeTop 10% of 2007 papers
Brent J. Yoder, Shugeng Cao, Andrew Norris, James S. Miller, Fidy Ratovoson, Jeremi Razafitsalama, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston
Abstract
Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC50 = 0.13 microM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 microM) was the most potent of the new compounds.
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