Cytotoxic Clerodane Diterpenoids and Their Hydrolysis Products from Casearia nigrescens from the Rainforest of Madagascar
Journal of Natural Products2007Vol. 70(2), pp. 206–209
Citations Over TimeTop 13% of 2007 papers
Russell B. Williams, Andrew Norris, James S. Miller, Chris Birkinshaw, Fidy Ratovoson, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston
Abstract
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 microM.
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