Prenylated Xanthones from the Root Bark of Cudrania tricuspidata
Journal of Natural Products2007Vol. 70(7), pp. 1207–1209
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Ji Hye Hwang, Seong Su Hong, Xiang Han, Ji Sang Hwang, Dongho Lee, Heesoon Lee, Yeo Pyo Yun, Young Soo Kim, Jai Seup Ro, Bang Yeon Hwang
Abstract
Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively.
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