Flavonoids as Opioid Receptor Ligands: Identification and Preliminary Structure−Activity Relationships

Citations Over TimeTop 10% of 2007 papers

Abstract

Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.

Related Papers

• → Synthesis and biological activity of substance P C-terminal hexapeptide analogues: structure-activity studies(1986)23 cited
• Structure-activity relationship of quinolone antibacterial agents: the effects of C-2 substitution.(1990)
• → Inhibition of Radioactive Depletion of Hemocytes and Antitumor Effects of Flavonoid(2021)1 cited
• Component Evaluation and Content Determination of Flavonoid in the leaves of Acanthopanan trifoliatus(2010)