Vanillic Acid Derivatives from the Green Algae Cladophora socialis As Potent Protein Tyrosine Phosphatase 1B Inhibitors
Journal of Natural Products2007Vol. 70(11), pp. 1790–1792
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Yunjiang Feng, Anthony R. Carroll, Rama Addepalli, Gregory A. Fechner, Vicky M. Avery, Ronald J. Quinn
Abstract
A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin cell signaling. Compounds 1 and 2 had IC50 values of 3.7 and 1.7 microM, respectively.
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