Naamidines H and I, Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge Leucetta chagosensis
Journal of Natural Products2007Vol. 70(10), pp. 1658–1660
Citations Over TimeTop 10% of 2007 papers
Sachiko Tsukamoto, Tetsuro Kawabata, Hikaru Kato, Tomihisa Ohta, Henki Rotinsulu, Remy E. P. Mangindaan, Rob W. M. van Soest, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi
Abstract
Two new imidazole alkaloids, naamidines H ( 1) and I ( 2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds ( 1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 microg/mL, respectively.
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