Spirolide Toxin Profile of Adriatic Alexandrium ostenfeldii Cultures and Structure Elucidation of 27-Hydroxy-13,19-didesmethyl Spirolide C
Journal of Natural Products2007Vol. 70(12), pp. 1878–1883
Citations Over TimeTop 10% of 2007 papers
Patrizia Ciminiello, Carmela Dell’Aversano, Ernesto Fattorusso, Martino Forino, Laura Grauso, Luciana Tartaglione, Franca Guerrini, Rossella Pistocchi
Abstract
This paper reports on the determination of the toxin profile of batch cultures of Alexandrium ostenfeldii established from water samples collected along the Emilia-Romagna coasts (Italy) in November 2003. Combined use of LC-MS/MS and 1D and 2D NMR techniques led us to identify 13,19-didesmethylspirolide C and 13-desmethylspirolide C as products of the alga and to highlight the occurrence of a new component, 27-hydroxy-13,19-didesmethylspirolide C, whose structure was fully elucidated by NMR. MS data for a number of minor spirolides are also reported.
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