Alkaloids from Stems and Leaves ofStemona japonicaand Their Insecticidal Activities
Journal of Natural Products2007Vol. 71(1), pp. 112–116
Citations Over TimeTop 17% of 2007 papers
Chunping Tang, Tong Chen, Robert Velten, Peter Jeschke, Ulrich Ebbinghaus‐Kintscher, Sven Geibel, Yang Ye
Abstract
Five new alkaloids, 6beta-hydroxystemofoline (1), 16-hydroxystemofoline (2), neostemofoline (3), protostemodiol (4), and 13-demethoxy-11(S*),12(R*)-dihydroprotostemonine (5), along with 10 known alkaloids, were isolated from stems and leaves of Stemona japonica. Their structures were elucidated by 1D and 2D NMR and other spectroscopic studies. The insecticidal activity of the agonist 16-hydroxystemofoline (2) and antagonist 13-demethoxy-11(S*),12(R*)-dihydroprotostemonine (5) was demonstrated by electrophysiological in vitro tests on the insect nicotinic acetylcholine receptor and by in vivo screenings against relevant agricultural insect pests.
Related Papers
- → α -Bungarotoxin binding to human muscle acetylcholine receptor: measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptides(1998)21 cited
- Effects of acute denervation on ratio change of nicotinic acetylcholine receptor subtypes in the rat gastrocnemius muscle(2008)
- → Monoclonal antibodies as probes of the acetylcholine receptor and myasthenia gravis(1984)25 cited
- → Antigenic specificity of acetylcholine receptor in developing muscle(1985)13 cited
- [Antibody against synthetic peptide corresponding to alpha-subunit residues 128-142 of nicotinic acetylcholine receptor (AChR): the significance in myasthenia gravis (MG)].(1988)