Antiproliferative Cassane Diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar Rainforest
Journal of Natural Products2007Vol. 71(1), pp. 150–152
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Yanpeng Hou, Shugeng Cao, Peggy J. Brodie, James S. Miller, Chris Birkinshaw, Fidisoa Ratovoson, R. Rakotondrajaona, Rabodo Andriantsiferana, Vincent E. Rasamison, David G. I. Kingston
Abstract
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively.
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