Hasubanan Alkaloids with δ-Opioid Binding Affinity from the Aerial Parts of Stephania japonica
Journal of Natural Products2010Vol. 73(5), pp. 988–991
Citations Over TimeTop 13% of 2010 papers
Anthony R. Carroll, Thirumavalavan Arumugan, Joanne Redburn, Ana Ngo, Gordon P. Guymer, Paul I. Forster, Ronald J. Quinn
Abstract
Two new (1 and 2) and six known hasubanan alkaloids (3-8) and one morphinane alkaloid (9) were isolated from the leaves of the North Queensland rainforest vine Stephania japonica. The structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR spectra. The hasubanan alkaloids showed affinity for the human delta-opioid receptor with IC(50) values ranging from 0.7 to 46 microM. The compounds were also tested for their affinity to micro- and kappa-opioid receptors and shown to be inactive against kappa-opioid receptors, but were of similar potency against the micro-opioid receptor.
Related Papers
- → (+)-Angchibangkine, a New Type of Bisbenzylisoquinoline Alkaloid, and Other Dimers from Pachygone dasycarpa(1997)21 cited
- → Triclisia sacleuxii(Pierre) Diels (Menispermaceae), a potential source of acetylcholinesterase inhibitors(2009)16 cited
- → Alkaloidal Constituents of the Leaves of Stephania cepharantha Cultivated in Japan: Structure of Cephasugine, a New Morphinane Alkaloid.(1997)14 cited
- → Cycleanine N-oxide, a New Alkaloid fromSynclisia scabrida(1983)13 cited
- → Alkaloids of the Leaves of Cocculus laurifolius DC. II. The Structure of Erythroculine(1970)5 cited