Onionin A from Allium cepa Inhibits Macrophage Activation
Journal of Natural Products2010Vol. 73(7), pp. 1306–1308
Citations Over TimeTop 10% of 2010 papers
Mona El‐Aasr, Yukio Fujiwara, Motohiro Takeya, Tsuyoshi Ikeda, Sachiko Tsukamoto, Masateru Ono, Daisuke Nakano, Masafumi Okawa, Junei Kinjo, Hitoshi Yoshimitsu, Toshihiro Nohara
Abstract
Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.
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