Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolens with a New Natural Product Framework
Journal of Natural Products2010Vol. 73(5), pp. 1008–1011
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Russell B. Williams, Jin‐Feng Hu, Krista M. Olson, Vanessa L. Norman, Matt G. Goering, Mark O’Neil-Johnson, Gary R. Eldridge, Courtney M. Starks
Abstract
High-throughput natural products chemistry methods have led to the isolation of three new (1-3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 microg/mL.
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