Antiplasmodial Triterpenoids from the Fruits of Neem, Azadirachta indica
Journal of Natural Products2010Vol. 73(8), pp. 1448–1452
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Giuseppina Chianese, Rakiswendé Serge Yerbanga, Leonardo Lucantoni, Annette Habluetzel, Nicoletta Basilico, Donatella Taramelli, Ernesto Fattorusso, Orazio Taglialatela‐Scafati
Abstract
Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
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