Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla
Journal of Natural Products2010Vol. 74(1), pp. 12–15
Citations Over TimeTop 12% of 2010 papers
Kou Wang, Xiaoyu Zhou, Yuanyuan Wang, Mingming Li, Yin-Shan Li, Li‐Yan Peng, Xiao Cheng, Yan Li, Yiping Wang, Qin‐Shi Zhao
Abstract
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.
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