Anti-inflammatory Triterpenes from the Leaves of Rosa laevigata
Journal of Natural Products2011Vol. 74(4), pp. 732–738
Citations Over TimeTop 13% of 2011 papers
Na Zeng, Yang Shen, Ling-Zhi Li, Wei‐Hua Jiao, Pinyi Gao, Shao‐Jiang Song, Wansheng Chen, Hou‐Wen Lin
Abstract
Bioassay-guided fractionation of an EtOAc extract of the leaves of Rosa laevigata afforded two new 19-oxo-18,19-seco-ursane-type triterpenes (1 and 3), a new ursane-type nortriterpene (2), a new ursane-type triterpene lactone saponin (4), and two new oleanane-type triterpenoids (5 and 6), together with eight known triterpenoids (7-14). Compound 1, a 19-oxo-18,19-seco-28-norursane, possesses a conjugated diene between C-12 and C-17. Several of the isolated compounds (1, 5, 7, 11, and 13) exhibited moderate activities in anti-inflammatory assays in vitro.
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