Kabiramides J and K, Trisoxazole Macrolides from the Sponge Pachastrissa nux
Journal of Natural Products2011Vol. 74(5), pp. 1288–1292
Citations Over TimeTop 12% of 2011 papers
Thanchanok Sirirak, Siriporn Kittiwisut, Chittrawan Janma, Supreeya Yuenyongsawad, Khanit Suwanborirux, Anuchit Plubrukarn
Abstract
Three trisoxazole macrolides possessing a 30-α,β-enone moiety, including the known kabiramide G (1) and the new kabiramides J (2) and K (3), were isolated from the sponge Pachastrissa nux, along with the previously reported kabiramides B (4), C (5), and D (6). To date, the enone moiety has been found to associate solely with the trisoxazole macrolides from P. nux. All of the isolated macrolides showed moderate to strong antimalarial and cytotoxic activities, except for 1, which possessed only potent cytotoxicity.
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