Bioactive Neolignans and Lignans from the Bark of Machilus robusta
Journal of Natural Products2011Vol. 74(6), pp. 1444–1452
Citations Over TimeTop 14% of 2011 papers
Yanru Li, Wei Cheng, Chenggen Zhu, Chun‐Suo Yao, Liang Xiong, Ye Tian, Sujuan Wang, Sheng Lin, Jin‐Feng Hu, Yongchun Yang, Ying Guo, Ying Yang, Yan Li, Yu‐He Yuan, Nai‐Hong Chen, Jian‐Gong Shi
Abstract
Sixteen new neolignans and lignans (1-16), together with 12 known analogues, have been isolated from an ethanol extract of the bark of Machilus robusta. Compounds 1 and 2 showed activity against HIV-1 replication in vitro, with IC(50) values of 2.52 and 2.01 μM, respectively. At 10 μM, 6, 8, and 9 reduced dl-galactosamine-induced hepatocyte (WB-F344 cells) damage, and 9 could additionally attenuate rotenone-induced PC12 cell damage. The known compounds (-)-pinoresinol (17) and (+)-lyoniresinol (18) were active against serum deprivation induced PC12 cell damage.
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