Antimalarial Activity of Physalins B, D, F, and G
Journal of Natural Products2011Vol. 74(10), pp. 2269–2272
Citations Over TimeTop 10% of 2011 papers
Matheus Santos de Sá, Maria N. de Menezes, Antoniana U. Krettli, Ivone Maria Ribeiro, Therezinha C.B. Tomassini, Ricardo Ribeiro dos Santos, Walter Filgueira de Azevedo, Milena Botelho Pereira Soares
Abstract
The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
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