Pseudoguaianolides and Guaianolides from Inula hupehensis as Potential Anti-inflammatory Agents
Journal of Natural Products2011Vol. 74(9), pp. 1881–1887
Citations Over TimeTop 16% of 2011 papers
Jiang‐Jiang Qin, Jiaxian Zhu, Qi Zeng, Xiang‐Rong Cheng, Yan Zhu, Shoude Zhang, Lei Shan, Hui‐Zi Jin, Weidong Zhang
Abstract
Eight new pseudoguaianolides (1-8), two new guaianolides (9 and 10), and 14 known sesquiterpenes were isolated from the aerial parts of Inula hupehensis. The structures were elucidated using spectroscopic methods and circular dichroism analysis. All compounds were tested for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 13 and 22 were found to inhibit nitric oxide production potently, with IC50 values of 0.9 and 0.6 μM, respectively. Preliminary structure-activity relationships for these compounds are proposed.
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