Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment
Journal of Natural Products2011Vol. 74(9), pp. 1965–1971
Citations Over TimeTop 10% of 2011 papers
Mostafa E. Rateb, Wael E. Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Bárbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars
Abstract
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
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