Phaeosphaerins A–F, Cytotoxic Perylenequinones from an Endolichenic Fungus,Phaeosphaeriasp.
Journal of Natural Products2012Vol. 75(2), pp. 142–147
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Gang Li, Haiying Wang, Rongxiu Zhu, Lingmei Sun, Li‐Ning Wang, Ming Li, Yaoyao Li, Yongqing Liu, Zun‐Tian Zhao, Hong‐Xiang Lou
Abstract
Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.
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