Asperolides A–C, Tetranorlabdane Diterpenoids from the Marine Alga-Derived Endophytic Fungus Aspergillus wentii EN-48
Journal of Natural Products2012Vol. 75(2), pp. 148–152
Citations Over TimeTop 10% of 2012 papers
Haofen Sun, Xiao‐Ming Li, Meng Li, Chuan‐Ming Cui, Shu‐Shan Gao, Chun‐Shun Li, Caiguo Huang, Bin‐Gui Wang
Abstract
Bioassay-guided fractionation of the culture extract of Aspergillus wentii EN-48, an endophytic fungus isolated from an unidentified marine brown algal species of the genus Sargassum, led to the isolation of three new tetranorlabdane diterpenoids, asperolides A-C (1-3), and five related derivatives (4-8). The structures of these compounds were established on the basis of spectroscopic interpretation, and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 1 was determined by application of the modified Mosher's method. An X-ray structure for wentilactone B (6) is also reported. Compounds 1-8 were evaluated for cytotoxic and antibacterial activities.
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