Daphmacromines A–J, Alkaloids from Daphniphyllum macropodum
Journal of Natural Products2012Vol. 75(6), pp. 1076–1082
Citations Over TimeTop 10% of 2012 papers
Mingming Cao, Yu Zhang, Hong‐Ping He, Shifei Li, Shengdian Huang, Duozhi Chen, Gui‐Hua Tang, Shun‐Lin Li, Ying‐Tong Di, Xiao‐Jiang Hao
Abstract
Ten new yuzurine-type Daphniphyllum alkaloids, daphmacromines A-J (1-10), along with seven known alkaloids were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The pesticidal and cytotoxic activities of the isolated alkaloids were evaluated in vitro against brine shrimp (Artemia salina) and five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), respectively. This study also suggested structural revisions of oxodaphnigracine, oxodaphnigraciline, and epioxodaphnigraciline.
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