Hepatoprotective Iridoid Glycosides from the Roots of Rehmannia glutinosa
Journal of Natural Products2012Vol. 75(9), pp. 1625–1631
Citations Over TimeTop 10% of 2012 papers
Yanfei Liu, Dong Liang, Huan Luo, Zhi‐You Hao, Yan Wang, Chun‐Lei Zhang, Qingjian Zhang, Ruo-Yun Chen, De‐Quan Yu
Abstract
Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 μM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
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