Terpecurcumins A–I from the Rhizomes of Curcuma longa: Absolute Configuration and Cytotoxic Activity
Journal of Natural Products2012Vol. 75(12), pp. 2121–2131
Citations Over TimeTop 25% of 2012 papers
Xionghao Lin, Shuai Ji, Rui Li, Yinhui Dong, Xue Qiao, Hongbo Hu, Wenzhi Yang, De‐an Guo, Pengfei Tu, Min Ye
Abstract
Terpecurcumins A-I (1-9), together with three known analogues (10-12), were isolated from the rhizomes of Curcuma longa (turmeric). They were derived from the hybridization of curcuminoids and bisabolanes. The structures and absolute configurations of 1-9 were elucidated on the basis of extensive spectroscopic data analysis, including NMR and electronic circular dichroism spectra. The configuration of 10 was further confirmed by X-ray crystallography. A plausible biogenetic relationship for 1-12 is proposed. Compounds 4, 6, 7, 10, and 11 showed higher cytotoxic activities (IC(50), 10.3-19.4 μM) than curcumin (IC(50), 31.3-49.2 μM) against human cancer cell lines (A549, HepG2, and MDA-MB-231).
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