Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
Journal of Natural Products2012Vol. 75(12), pp. 2251–2255
Citations Over TimeTop 10% of 2012 papers
Xiao Zhou, Hongbo Huang, Yuchan Chen, Jia‐Heng Tan, Yongxiang Song, Jianhua Zou, Xinpeng Tian, Yan Hua, Jianhua Ju
Abstract
A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 μg/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC(50) values ranging from 0.38 to 0.52 μM.
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