Cytotoxic Cyclic Depsipeptides from the Australian Marine Sponge Neamphius huxleyi
Journal of Natural Products2012Vol. 75(12), pp. 2200–2208
Citations Over TimeTop 10% of 2012 papers
Trong D. Tran, Ngoc Bich Pham, Gregory A. Fechner, Dusan Zencak, Hoan Vu, John N. A. Hooper, Ronald J. Quinn
Abstract
Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MS(n). Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC(50) values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound.
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