Khayseneganins A–H, Limonoids from Khaya senegalensis
Journal of Natural Products2012Vol. 76(3), pp. 327–333
Citations Over TimeTop 23% of 2012 papers
Chun‐Mao Yuan, Yu Zhang, Gui‐Hua Tang, Ying‐Tong Di, Mingming Cao, Xiaoying Wang, Guo‐Ying Zuo, Shun‐Lin Li, Huiming Hua, Hong‐Ping He, Xiao‐Jiang Hao
Abstract
Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 μg/mL.
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