Antidepressant Abietane Diterpenoids from Chinese Eaglewood
Journal of Natural Products2013Vol. 76(2), pp. 216–222
Citations Over TimeTop 10% of 2013 papers
Lin Yang, Lirui Qiao, Chengxue Ji, Dan Xie, Ningbo Gong, Yang Lü, Jianjun Zhang, Jungui Dai, Shun‐Xing Guo
Abstract
Ten new abietane diterpenoids, aquilarabietic acids A-J (1-10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 μM demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC(50) value of 9.1 × 10(-7) M.
Related Papers
- → Three New Diterpenoids from Euphorbia wallichii(2004)30 cited
- → 16-hydroxycarnosic acid, a diterpene from Salvia apiana(1990)26 cited
- → New Diterpenes from the Heartwood of Chamaecyparis obtusa var. formosana(1998)27 cited
- → Salvidorol, a nor-abietane diterpene with a rare carbon skeleton and two abietane diterpene derivatives from Salvia dorrii(2006)25 cited
- → New adduct of abietane-type diterpene from Salvia leriifolia Benth.(2016)15 cited