Xanthoquinodins from the Endolichenic Fungal Strain Chaetomium elatum
Journal of Natural Products2013Vol. 76(4), pp. 702–709
Citations Over TimeTop 10% of 2013 papers
Guo‐Dong Chen, Ying Chen, Hao Gao, Li-Qing Shen, Yang‐Chang Wu, Xiaoxia Li, Yan Li, Liang‐Dong Guo, Ying‐Zhou Cen, Xin‐Sheng Yao
Abstract
Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.
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