Cytotoxic Deoxybenzoins and Diphenylethylenes from Arundina graminifolia
Journal of Natural Products2013Vol. 76(10), pp. 1854–1859
Citations Over TimeTop 10% of 2013 papers
Qiu‐Fen Hu, Bin Zhou, Yanqing Ye, Zhi‐Yong Jiang, Xiang‐Zhong Huang, Yin-Ke Li, Gang Du, Guangyu Yang, Xuemei Gao
Abstract
Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.
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