Cytotoxic Oxepinochromenone and Flavonoids from the Flower Buds of Rosa rugosa
Journal of Natural Products2013Vol. 76(10), pp. 1866–1871
Citations Over TimeTop 12% of 2013 papers
Qiu-Fen Hu, Bin Zhou, Jian Huang, Zhi-Yong Jiang, Xiang-Zhong Huang, Li-Ying Yang, Xue-Mei Gao, Guang‐Yu Yang, Chun-Tao Che
Abstract
A new oxepinochromenone, rugosachromenone A (1), seven new flavonoids, rugosaflavonoids A-G (2-8), and 11 known compounds (9-19) were isolated from the flower buds of Rosa rugosa. Compound 1 is found from Nature for the first time. Compound 2 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cells with IC50 values of 2.2, 2.5, and 2.3 μM, respectively, and 3 was toxic to A549 and MCF7 cells with IC50 values of 1.2 and 2.8 μM, respectively.
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