Mycoleptones A–C and Polyketides from the EndophyteMycoleptodiscus indicus
Journal of Natural Products2014Vol. 77(1), pp. 70–78
Citations Over TimeTop 20% of 2014 papers
Willian Jonis Andrioli, Raphael Conti, Magali J. Araújo, Riccardo Zanasi, Bruno Coêlho Cavalcanti, Viviane Manfrim, Juliano Simões de Toledo, Daniele Tedesco, Manoel Odorico de Moraes, Cláudia Pessoa, Ângela K. Cruz, Carlo Bertucci, J.R. Sabino, Dhammika Nanayakkara, Mônica Tallarico Pupo, Jairo Kenupp Bastos
Abstract
Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays.
Related Papers
- → Endophyte infection can contribute to aluminum tolerance in fine fescues(2001)54 cited
- → Alkaloid Production and Chinch Bug Resistance in Endophyte-Inoculated Chewings and Strong Creeping Red Fescues(2000)32 cited
- → Contrasting Toxic‐Endophyte Contamination between Endophyte‐Free and Nontoxic‐Endophyte Tall Fescue Pastures(2005)15 cited
- → Ryegrass endophyte: host/fungus interaction(1999)12 cited
- 'Lacefield MaxQll' Novel Tall Fescue(2016)