Evaluation of Anti-Inflammatory Activity of Prenylated Substances Isolated from Morus alba and Morus nigra
Journal of Natural Products2014Vol. 77(6), pp. 1297–1303
Citations Over TimeTop 10% of 2014 papers
Hana Zelová, Zuzana Hanáková, Zdeňka Čermáková, Karel Šmejkal, Stefano Dall’ Acqua, Petr Babula, Josef Cvačka, Jan Hošek
Abstract
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
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