Identification and Bioactivity of 3-epi-Xestoaminol C Isolated from the New Zealand Brown Alga Xiphophora chondrophylla
Journal of Natural Products2014Vol. 77(6), pp. 1519–1523
Citations Over TimeTop 11% of 2014 papers
Nathaniel Dasyam, Andrew B. Munkacsi, Nazmi Harith-Fadzilah, Dinindu Senanayake, Ronan O’Toole, Robert A. Keyzers
Abstract
We report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.
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