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Antitumor Agents, 79. Cytotoxic Antileukemic Alkaloids from Brucea antidysenterica
Journal of Natural Products1986Vol. 49(3), pp. 428–434
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Narihiko Fukamiya, Masayoshi Okano, Takaaki Aratani, Kenji Negoro, Andrew T. McPhail, Motoharu Ju‐ichi, Kuo‐Hsiung Lee
Abstract
Two cytotoxic antileukemic alkaloids, the new 1,11-dimethoxycanthin-6-one (3) and the known 11-hydroxycanthin-6-one (1), as well as the known canthin-6-one (2) were isolated from the stem of Brucea antidysenterica. The structures of 1-3 were determined from their spectral data and X-ray analysis of the o-bromobenzoate of 1.
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