Eurifoloids A–R, Structurally Diverse Diterpenoids from Euphorbia neriifolia
Journal of Natural Products2014Vol. 77(10), pp. 2224–2233
Citations Over TimeTop 10% of 2014 papers
Abstract
Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 μM (SI = 10.3), respectively.
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