Faeriefungin: A New Board-Spectrum Antibiotic from Streptomyces griseus var. autotrophicus

Citations Over TimeTop 24% of 1989 papers

Abstract

Faeriefungin, a polyol polyene macrolide lactone antibiotic, was isolated from the mycelium of Streptomyces griseus var. autotrophicus, MSU-32058/ATCC 53668, collected from the soil sample of a fairy ring in an old lawn in Lansing, Michigan. Faeriefungin has some properties similar to the previously reported polyene macrolides, mycoticin and flavofungin, but possesses different physiochemical and biological properties. Aspergillus, Fusarium, Microsporum, Trichophyton, and Alternaria spp. were completely inhibited by faeriefungin at 3.2 micrograms/ml, Candida spp. at 5.5 micrograms/ml, and Pythium, Phialophora, Leptosphaeria spp., and some selected Gram-negative penicillin-resistant strains of Neisseria gonorrhoeae at 16.0 micrograms/ml. At a concentration of 100 ppm, it caused 100% mortality of mosquito larvae (Aedes aegypti, Rockefeller strain) and free-living nematodes (Panagrellus redivivus). Unlike the related polyene macrolides, faeriefungin is crystalline and stable with broad-spectrum antimicrobial and insecticidal activity. Preliminary cytotoxicity studies with human erythrocytes and rat liver epithelial cells indicated that faeriefungin and amphotericin B have comparable toxicity. Solution nmr study has indicated that faeriefungin is a mixture of two compounds, faerifungins A [1] and B [2], and that they differ in the attachment of a H or an Me at C-33.

Related Papers

• → Antibiotics produced by Streptomyces(2012)729 cited
• [Metabolic studies on Streptomyces griseus cultures. I. Determination of changes of redox potential, dried residue, reducing substance and catalase activity in Streptomyces griseus cultures].(1958)
• → Studies on an Enzyme Capable of Splitting β-d-1,6-Glucosidic Linkage(1963)1 cited
• → Studies on the Utilization of Streptomyces griseus Protease. Part I(1960)
• Detection and changes of nucleotide pyrophosphotransferase activity of Streptomyces griseus strains in submerged culture.(1979)