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Antineoplastic Agents, 107. Isolation of Acteoside and Isoacteoside from Castilleja linariaefolia
Journal of Natural Products1990Vol. 53(2), pp. 456–458
Citations Over TimeTop 14% of 1990 papers
George R. Pettit, Atsushi Numata, Tsuruko Takemura, Richard H. Ode, Acharan S. Narula, Jean M. Schmidt, Gordon M. Cragg, Charles P. Pase
Abstract
The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.
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