Plant Anticancer Agents, XLVIII. New Cytotoxic Flavonoids from Muntingia calabura Roots
Citations Over TimeTop 14% of 1991 papers
Abstract
From a cytotoxic Et2O-soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1-7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1-12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on 1H-1H COSY, 1H-13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines.
Related Papers
- → Flavones: A direct synthesis of 6-hydroxy-flavones(1951)1 cited
- → Synthetic studies on flavone derivatives. XIV. Synthesis of 2',4',5'-trioxygenated flavones.(1984)17 cited
- Study on Technology of Separation and Purification for Flavones in Lotus Leaf by HP-20(2007)
- Study on the Antioxidant Activity of Raspberry Flavones(2012)
- → Chromones and Flavones. Part IV Chloromethylation of Some Chromones and Flavones(1962)