Hupehenols A–E, Selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors from Viburnum hupehense
Journal of Natural Products2015Vol. 78(2), pp. 330–334
Citations Over TimeTop 10% of 2015 papers
Xuan‐Qin Chen, Li‐Dong Shao, Mahesh Pal, Yu Shen, Xiao Cheng, Gang Xu, Li‐Yan Peng, Kou Wang, Zheng‐Hong Pan, Mingming Li, Ying Leng, Juan He, Qin‐Shi Zhao
Abstract
Five selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) competitive inhibitors, hupehenols A-E (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols A-E (1-5) showed inhibition against human 11β-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11β-HSD1 when compared to murine 11β-HSD1.
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