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Scoparic Acid A, a β-Glucuronidase Inhibitor from Scoparia dulcis
Journal of Natural Products1992Vol. 55(12), pp. 1748–1755
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Toshimitsu Hayashi, M. Kawasaki, Kana Okamura, Yoko Tamada, Naokata Morita, Yasuhiro Tezuka, Tohru Kikuchi, Yoshihisa Miwa, Tooru Taga
Abstract
The 70% EtOH extract of Scoparia dulcis showed inhibitory activity against beta-glucuronidase from bovine liver. Bioassay-directed fractionation of the active extract led to the isolation of three labdane-type diterpene acids, scoparic acid A [1] [6-benzoyl-12-hydroxy-labda-8(17), 13-dien-18-oic acid], scoparic acid B [2] [6-benzoyl-14,15-dinor-13-oxo-8(17)-labden-18-oic acid], and scoparic acid C [3] [6-benzoyl-15-nor-14-oxo-8(17)-labden-18-oic acid], the structures of which were established by spectral means, including X-ray analysis. Scoparic acid A was found to be a potent beta-glucuronidase inhibitor.
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