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New Leukotriene B4 Receptor Antagonist: Leucettamine A and Related Imidazole Alkaloids from the Marine Sponge Leucetta microraphis
Journal of Natural Products1993Vol. 56(1), pp. 116–121
Citations Over TimeTop 10% of 1993 papers
George W. Chan, Seymour Mong, Mark E. Hemling, Alan J. Freyer, Priscilla Offen, Charles DeBrosse, Henry M. Sarau, John Westley
Abstract
Three new imidazole alkaloids, leucettamines A [1] and B [2] and leucettamidine [3], have been isolated from the Palauan sponge Leucetta microraphis. Their structures were established on the basis of extensive spectral analyses. Leucettamine A showed potent leukotriene B4 receptor binding activity (K(i) = 1.3 microM), while leucettamine B was essentially inactive (K(i) = 100 microM) and leucettamidine showed significant activity (K(i) = 5.3 microM). With leucettamine A identified as a pure LTB4 receptor antagonist, a new structure lead is presented to inflammation therapy.
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