Striatoids A–F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the FungusCyathus striatus
Journal of Natural Products2015Vol. 78(4), pp. 783–788
Citations Over TimeTop 10% of 2015 papers
Abstract
Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A-F (1-6), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, (1)H-(1)H-COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4'-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.
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