Lupane-Type Triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the Apoptotic Effect of 28-Hydroxy-3-oxo-lup-20(29)-en-30-al
Journal of Natural Products2008Vol. 71(8), pp. 1352–1357
Citations Over TimeTop 23% of 2008 papers
I-Hsiao Chen, Ying-Chi Du, Mei‐Chin Lu, An‐Shen Lin, Pei‐Wen Hsieh, Chin‐Chung Wu, Shuli Chen, Hsin‐Fu Yen, Fang‐Rong Chang, Yang‐Chang Wu
Abstract
Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1- 4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.
Related Papers
- → In Vitro Cytotoxicity Analysis: MTT/XTT, Trypan Blue Exclusion(2023)15 cited
- → Amitorin, a Cytotoxic Diterpenoid from a Sponge Halichondria sp.(2022)2 cited
- → Assessment of cytotoxicity upconversion nanoparticles coated by SiO2 on different cell lines(2022)1 cited
- Cell-mediated allograft responses in vitro. VI. Studies on macrophage-mediated cytotoxicity.(1975)
- → Investigation of the human macrophage II. The in vitro cytotoxicity of macrophages(1979)2 cited