Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
Journal of Natural Products2008Vol. 71(6), pp. 1095–1098
Citations Over TimeTop 10% of 2008 papers
Abstract
There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
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