Cytotoxic Triterpenoids from the Stems of Microtropis japonica
Journal of Natural Products2009Vol. 72(7), pp. 1231–1236
Citations Over TimeTop 22% of 2009 papers
I-Hsiao Chen, Mei‐Chin Lu, Ying-Chi Du, Ming‐Hong Yen, Chin‐Chung Wu, Yung‐Husan Chen, Chih‐Sheng Hung, Shuli Chen, Fang‐Rong Chang, Yang‐Chang Wu
Abstract
Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
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