Acylated Iridoids with Cytotoxicity from Valeriana jatamansi
Journal of Natural Products2009Vol. 72(4), pp. 650–655
Citations Over TimeTop 1% of 2009 papers
Sheng Lin, Yun‐Heng Shen, Hui‐Liang Li, Xian‐Wen Yang, Tao Chen, Long-Hai Lu, Zheng‐Sheng Huang, Runhui Liu, Xi‐Ke Xu, Weidong Zhang, Hui Wang
Abstract
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.
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